Son of a Bitch: The Insano Theory.

Good god I love Dr. Insano. He is awesome.

Whenever Insano and Linkara interact, it is brought up that they are arch enemies. Linkara has given himself an interesting role in that he is pretty much a superhero, having an array of weapons, some powers and and his own rogues gallery (Insano, Neautro, Mechakara, Lord Vice, Linksano, Phantasm, Pyramid Head). By what I understand, this was not initially intentional and originally started as somewhat of a series jokes because of his reviewing of comic books, a medium dominated by superheroes. This was pretty much cemented in the episode when he fought the Star Trek comic. Insano has repeatedly shown up against Linkara, officially granting him the role of arch villain.

But the weird thing is, he hasn't actually had a sort of 'Final Confrontation' with our hero. Last year, Insano's arch nemesis duties were mostly taken over by Mechakara, who was a pretty damn good villain. Insano eventually made a reappearance to finally kill Mechakara (though this appears to have been undone), and has appeared several times since, most memorably in the Warrior #2-3 review (Which blew my mind!). However, Linkara had the epic showdown with Mechakara, making him seem much more like the primary villain, which in this case was technically true.

Now we are getting Lord Vice, who is shaping up to be pretty cool, but Insano is again left in the dust. According to Linkara, this is because he felt bad about constantly asking Spoony to dress up all the time for it, so it's understandable, and we got the hilarious Linksano out of it.
In fact, Insano has only actually gotten one actual fight with Linkara that I'm aware of, the Adamantium Rage review, which was cool, but quick, and that's fine, they gave us a lot in a little. This brings up the fact that while Insano's lack of appearances as an actual arch enemy is causing me to complain, there is actually an interesting side to it.

It's no secret of how popular Insano is. His appearances are often massive CMoF's, and Spoony clearly enjoys the role, so whenever he DOES appear on Atop the Fourth Wall, it's always going to be great. This leads to what I'm going to call the Insano Theory, though I doubt theory is even the right term for it.
Insano is a villain labeled as the main villain of the series, but is overshadowed by the antagonist of the current storyline. We all remember Insano and it's unlikley we will forget him, even if the current villain is calling all the shots and Insano is nowhere to be seen. This could be considered a Sub-Trope of Ensemble Darkhorse, but it is nowhere near developed enough to actually even qaulify for a TV Tropes Page. So, if you could perhaps help me think of how it could work, then I would thank you.

And yes, I did add the Son of A Bitch title after writing most of this. I just felt I still needed to have SOME recurring segments actually recur.